One of the salient processes involved in manufacturing medications is wet granulation. This is an attractive option vs alternative methods of granule manufacturing such as dry granulation. Improving the quality and stability of medicines to a level better than ever before is also possible through wet granulation. And, it is also a lower-cost solution to produce high-quality medications for human use.
In wet granulation liquid binder is used, to produce small pieces called granules. This fluid could be just ordinary water or various other liquids, including ethanol or isopropyl alcohol. The granulation is then dried and screened to ensure all the resulting granules are of the same particle size. Which can then be pressed into tablets or filled into capsules, which is how people take their medicine.
Wet granulation has several advantages in the process of producing medicines. In oral consumption of the medicine, it creates greater absorption in the body, one great advantage. This occurs since wet granulation reduces the size of the particles, making it a lot more effective for the body to break down and also absorption of medicine.
Improved Flow and Pressability Spheronizer (tablets or capsules) — This is another important wet granulation advantage! They are also easier to swallow when these granules are properly made. Being able to do this is important because it can help people medicating themselves without any issues. Well, uniformity of granules means that each dose of medicine will be similar, ensuring every patient gets an accurate amount.
Every method has its pros and cons, so wet granulation too is not an exception. For things like the ability to produce uniform particles which then can easily be compressed into tablets, capsules, and so on. This consistency is crucial to ensure the medication will be effective. The process can also enhance the stability and absorption of the medicines, making them more effective in the body.
The beauty of this method comes at a cost though. Wet granulation is a laborious process and often necessitates large amounts of specialized equipment. Cost of the process will also be on the higher side because this equipment will have a hefty pricing tag. Furthermore, where liquid binders are employed, it may be difficult to control the moisture content of granules. We also know that too dry or too wet material can lead stuff to negatively impact up on the final product.
Improving wet granulation vibrating sifter involves considering a variety of different factors. Those factors are the drug class, excipients, and liquid binder; slurry type during process. We also have wet granulation to take into account the use of equipment application, time for processing and drying conditions for granules produced.
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